Vascular effects of the vascular targeting agent NGR-hTNF in patients with advanced solid cancer: a dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) study
نویسندگان
چکیده
I. Desar, C. M. van Herpen, J. J. van Asten, W. Fiedler, A. Govaerts, J. N. Timmer-Bonte, E. G. ter Voert, A. Lambiase, C. Bordignon, A. Heerschap, and H. W. van Laarhoven Medical Oncology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, Radiology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, Universitäts-Krankenhaus Hamburg-Eppendorf, Hamburg, Germany, EORTC Headquarters, Brussels, Belgium, Molmed, Milan, Italy
منابع مشابه
Phase I clinical and magnetic resonance imaging study of the vascular agent NGR-hTNF in patients with advanced cancers (European Organization for Research and Treatment of Cancer Study 16041).
PURPOSE This phase I trial investigating the vascular targeting agent NGR-hTNF aimed to determine the (a) dose-limiting toxicities, (b) maximum tolerated dose (MTD), (c) pharmacokinetics and pharmacodynamics, (d) vascular response by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and (e) preliminary clinical activity in solid tumors. EXPERIMENTAL DESIGN NGR-hTNF was administe...
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تاریخ انتشار 2009